Allogeneic bone marrow transplantation for acute myeloid leukemia in first remission.

Evidenee that eonventional treatment (ehemotherapy and/or immunotherapy) produees a substantial number of eures in aeute myeloid leukaemia (AML) is laeking (PowIes et al. 1980a). Thomas et al. (1977) showed that there was a proportion of long-term survivors of a group of AML patients treated with high-dose eyc1ophosphamide, total body irradiation (TBI) and allogeneie bone marrow transplantation (BMT). The purpose of the study reported he re is to define the plaee for BMT in the treatment of AML and involves a eomparison of two groups of first remission patients treated either with BMT or ehemoimmunotherapy. This study is an extension of the results published earlier this year (PowIes et al. 1980e).